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At present, the COVID-19 pandemic is still spreading rapidly. According to Google’s real-time statistics, until November 24, 2020, there have been more than 61 million total cases worldwide and more than 1.4 million deaths globally. The outbreak of SARS-CoV-2 threatens the global medical system and economy, and rules our daily lives. To control the outbreak of SARS-CoV-2 has become the most important and urgent in the world. However, as of October 2020, there are no drugs or treatments that can effectively combat SARS-CoV-2. Quick and sensitive diagnosis is the most importantly demanded, and some scientists are also focusing on more discoveries on SARS-CoV-2 with the help of magnetic nanoparticles.
For example, in the paper Rapid and sensitive detection of SARS-CoV-2 with functionalized magnetic nanoparticles which is published in arXiv, the researchers used an approach for rapid and sensitive detection of SARS-CoV-2 with functionalized homogeneous biosensing based on magnetic nanoparticles (MNPs) via the measurement of their magnetic response in an ac magnetic field. This study shows that the proposed approach allows the rapid detection of mimic SARS-CoV-2 with a limit of detection of 0.084 nM (5.9 fmole). And they summed up the proposed approach has great potential for designing a low-cost and point-of-care device for rapid and sensitive diagnostics of SARS-CoV-2.
With a comprehensive list of immunomagnetic bead products conjugated with different coating materials and functional groups in multiple sizes to meet research and industrial prospect development needs, Creative Diagnostics currently also offers SARS-CoV-2 Magnetic Particles for global researchers to capture and quantify anti-SARS-CoV-2 antibodies.
Scientists are accessible to a variety of Creative Diagnostics’ SARS-CoV-2 Magnetic Particles for their research. For example, Absolute Mag™ SARS-CoV-2 Spike protein RBD Conjugated Magnetic Particles (# WHM-AB05 #), which are obtained by coupling the biotinylated SARS-CoV-2 Spike RBD protein to streptavidin conjugated magnetic particles, and can capture the Anti- SARS-CoV-2 antibody or ACE2 protein from cell or serum sample and easily follow up with other tests, such as immunocapture, biopanning and flow cytometry. These magnetic particles will be supplied as lyophilized powder (from 0.22 μm filtered PBS pH7.4 including 0.05% Tween-20 and 10% trehalose).
About the author
CD Bioparticles is a leading manufacturer of magnetic particles and related products for immunoassay development. Scientists at CD Bioparticles are proficient in conjugating various bioaffinity ligands to magnetic beads to meet its customer’s needs. These ligands include but not limited to antibody, biotin, streptavidin, lectin, oligo(dT) and protein A/G.
Reference
Zhong, J., Roesch, E. L., Viereck, T., Schilling, M., & Ludwig, F. (2020). Rapid and sensitive detection of SARS-CoV-2 with functionalized magnetic nanoparticles. arXiv preprint arXiv:2010.03886.