Magnetic Particles

What Are Lanthanide-Based Magnetic Particles?

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Lanthanide-based magnetic particles are superparamagnetic magnetic particles formed by the reaction of a strong lanthanide (Ln) single-electron oxidant with Massart magnetite under high-power ultrasound irradiation. These particles have a γ-Fe2O3 core, and are positively charged and hydrophilic, which are not easy to aggregate in aqueous suspension/ferrofluid due to electrostatic repulsion. Since the lanthanide element has a characteristic oxidation state of +3 valence, it easily reacts with the Lewis base, so the particles can also be further functionalized.

  1. What are magnetic properties of lanthanides?

Lanthanides tend to react with oxygen to form oxides. Due to the presence of unpaired electrons in the f orbital, lanthanides exhibit strong electromagnetic and optical properties. Most lanthanides are paramagnetic, which means they have a strong magnetic field.

  1. What are iron oxide magnetic nanoparticles?

Magnetic iron oxide nanoparticles (MIONs) typically refer to the materials that consist of magnetite (Fe3O4) or maghemite (γ-Fe2O3) and have a size ranging from 1 to 100 nm. MIONs can disperse in biological fluids as a result of the Néelian and Brownian relaxations and yet respond to an external magnetic field.

  1. How do you make Fe3O4 nanoparticles?

Fe3O4 magnetic nanoparticles (MNPs) are synthesized by a co-precipitation method using sodium citrate and oleic acid as modifiers. Phase composition and microstructure analysis indicate that the sodium citrate and oleic acid have been successfully grafted onto the surface of Fe3O4 nanoparticles.

  1. What is the importance of iron oxide nanoparticles?

Iron oxide nanoparticles, with their superparamagnetic properties, are used in a rapidly expanding number of applications, such as for cell labeling, separation, and tracking; for therapeutic agents in cancer therapy; and for diagnostic agents.

  1. What are CAN-Fe2O3 nanoparticles?

CAN-Fe2O3 Nanoparticles are produced with two critical reaction materials, Massart magnetite (Fe3O4) nanoparticle (NPs)and Ceric Ammonium Nitrate [CAN, CeIV(NH4)2(NO3)6], and Fe3O4 is converted into Fe2O3 as particle core after reaction while CAN encloses a layer of [CeLn]3+/4+ cations on the outer surface of the core.

The shell [CeLn]3+/4+ complexes can bind and/or chelate with Lewis base mono and multi-dentate ligands including chelating polymers like a poly-cationic endosomolytic 25 kDa branched b-PEI polymer to create PEI25-CAN- Fe2O3, which enables siRNA/microRNA electrostatic capture and stabilization, cell delivery, and gene silencing. CAN-Fe2O3 nanoparticles are especially recommended for innovatively gene silencing application.

  1. Lanthanide-Based magnetic particles for research use?

As a leading manufacturer of magnetic particles and related products for immunoassay development, CD Bioparticles offers various Absolute Mag™ Lanthanide-Based Magnetic Particles for research applications. For instance, Absolute Mag™ CAN-Fe2O3 Magnetic Nanoparticles,40 nm are excellent for gene silencing applications, which are generated by the reaction of Fe2O3 magnetite nanoparticles and a strong mono-electronic oxidant CAN (Ceric Ammonium Nitrate, CeIV(NH4)2(NO3)6).

References
1. Tong, S., Zhu, H., & Bao, G. (2019). Magnetic iron oxide nanoparticles for disease detection and therapy. Materials Today, 31, 86-99.
2. Wei, Y., Han, B., Hu, X., Lin, Y., Wang, X., & Deng, X. (2012). Synthesis of Fe3O4 nanoparticles and their magnetic properties. Procedia Engineering, 27, 632-637.
3. Heo, D. N., Min, K. H., Choi, G. H., Kwon, I. K., Park, K., & Lee, S. C. (2014). Scale-Up Production of Theranostic Nanoparticles. In Cancer Theranostics (pp. 457-470). Academic Press.